Current Openings

Tarveda Therapeutics, Inc. is a clinical stage biotechnology company that discovers and develops Pentarins®, a new class of potent and selective miniaturized drug conjugates with enhanced targeting capabilities for the treatment of solid cancer tumors. Tarveda’s lead Pentarin drug candidate, PEN-221, is a miniaturized drug conjugate that targets the somatostatin receptor 2 (SSTR2) for treatment of patients with neuroendocrine and small cell lung cancers. PEN-221 comprises a highly selective peptide that targets SSTR2 linked to the potent cytotoxic DM1 through a cleavable linker.

Tarveda is also advancing its HSP90 drug conjugate platform with lead drug candidate PEN-866, which is a miniaturized HSP90 targeting drug conjugate that comprises a small molecule HSP90 targeting ligand conjugated to SN-38, the highly potent, active metabolite of irinotecan. Tarveda’s strategy includes developing its own proprietary Pentarins as well as applying the Pentarin platform to enhance the effectiveness of the targeting moieties and novel payloads of pharmaceutical collaborators.

Position Summary:

The Senior Scientist, Analytical Development/CMC will work in multi-disciplinary teams in a fast-paced environment to advance preclinical and clinical programs at Tarveda. The Senior Scientist will be responsible for execution of internal and outsourced analytical activities spanning pre‐clinical research and clinical program development. Additionally, the Senior Scientist will oversee key GMP regulated activities from initial feasibility and technology transfer through analytical method validation, material release, and stability testing.

Essential Functions:

  • Technical project leadership and lab contributions, spanning multiple initiatives in small molecule analytical and formulation development and CMC support.
  • Technical and project management of GMP operations and testing vendors’ analytical / QC work, maintaining clear and efficient business relationships with vendors
  • Contribute to strategy and execution relevant to Phase 2 & 3 clinical programs.
  • Collaborate with peers and effectively work in an energized, fast‐paced and cross‐functional results-oriented research team environment to deliver the objectives of Tarveda in a timely and cost-efficient manner that meets quality requirements.
  • Design, perform and lead internal and external analytical work supporting product development, characterization and understanding for process chemistry drug substance, drug product, and key raw materials and intermediates.
  • Oversee and execute analytical and technology transfer activities, methods validation, material release and stability, OOS/OOT investigations.
  • Author SOP, methods, protocols, reports, CoA, and contribute to regulatory submissions.
  • Interact closely with Quality, Process Chemistry, Drug Product Formulations, and management to provide project updates, workflows, and timelines/budgets.

Education and Experience:

  • Ph.D. in chemistry with 5+ years’ experience or B.S./M.S. with 8+ years of analytical experience in a regulated environment is required.
  • Deep understanding of analytical methodologies common to the pharmaceutical industry (e.g. HPLC, GC, MS, wet chemistry and process controls) to provide technical expertise towards methods development, quality control, and troubleshooting both internal and external.
  • Established background in analytical development, and technical QC in a regulated environment.
  • Experience with managing and mentoring of less experienced scientific staff members.
  • Experience with vendor management of CMOs and/or CTLs for Drug Substance and Drug Products (Parenteral) programs is strongly preferred.

Required Competencies:

  • Team oriented
  • Effective communicator (written and verbal)
  • Detail oriented
  • Independent/self-motivated
  • Vendor Management
  • Results oriented
  • Multi-tasking
  • Strong sense of urgency

Some travel required, less than 10%

Tarveda Therapeutics is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law.

Please send your resume and a brief cover letter describing why you should be considered for the position to the

Tarveda Therapeutics, Inc., 134 Coolidge Ave., Watertown, MA 02472